They are administered via intramuscular injection, typically on a weekly basis
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In contrast, certainty of evidence for tirzepatide compared to placebo at the agent-level was consistently low across outcomes, primarily driven by indirect-only evidence and concerns related to transitivity, with additional downgrading for imprecision or heterogeneity in select endpoints (Supplementary Table S25)
Both are effectiveIM shots are quicker and dont require an IV line